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Nhlbi Metabolic Syndrome. The World Health Organization WHO first developed its definition in 1998 Alberti and Zimmet 1998Because insulin resistance was felt to be central to the pathophysiology of metabolic syndrome evidence for insulin resistance is an absolute requirement in the WHO. Current definitions of metabolic syndrome.
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Nehal Mehta preventive cardiologist and head of NHLBIs Laboratory of Inflammation and Cardiometabolic Diseases. View Chap 7 Metabolic Syndromepdf from FREE 1 at Université Libanaise. Practice Essentials Metabolic syndrome syndrome X insulin resistance is a multifactorial disease with multiple risk factors that arises from insulin resistance accompanying abnormal adipose deposition and function.
The World Health Organization WHO first developed its definition in 1998 Alberti and Zimmet 1998Because insulin resistance was felt to be central to the pathophysiology of metabolic syndrome evidence for insulin resistance is an absolute requirement in the WHO.
Table 1 summarizes four of the most commonly used definitions of metabolic syndrome. Increased waist circumference elevated triglyceride levels BP fasting glucose level and reduced HDL-C levels. When diabetes becomes clinically apparent CVD risk rises sharply. The metabolic syndrome most people with this syndrome have insulin resistance which confers increased risk for type 2 diabetes.
